Chief Curator at Tate Modern since 2001, Wagstaff is responsible for an extensive international programme of major exhibitions, turbine hall commissions and collection displays at Tate Modern. Personally curating presentations of Eva Hesse (2002), followed by Edward Hopper, Jeff Wall: Photographs 1978-2004 and Juan Munoz : A Retrospective, she has also conceived a number of innovative programming initiatives including the Level 2 series of contemporary artists' projects as well as introduced new programme strands for photography, live art, performance and film
Wagstaff joined Tate in 1998 as Head of Exhibitions & Collection Displays responsible for devising an exhibition and collection-display programme for Tate Britain which opened in 2000. She also curated Mona Hatoum and the first exhibition of Darren Almond to launch a new series of contemporary responses to the work of JMW Turner.
From 1993-98, Wagstaff was Director of Exhibitions, Collections and Education at The Frick Art Museum, Pittsburgh, where she curated a programme of historic and contemporary exhibitions, served on the Museums Panel for the Pennsylvania Council on the Arts, Harrisburg, and was city cultural leader for Leadership Pittsburgh 1994-5. Previously, she worked at the Whitechapel Art Gallery, London, and the Museum of Modern Art, Oxford. She was the first British participant in the Whitney Museum of American Art�s Independent Study Program (1982-3).
Wagstaff is an elected board member of CIMAM (International Committee of ICOM for Museums and Collections of Modern Art), the International Advisory Council for Istanbul Modern, the Advisory Board of the Mattress Factory, Pittsburgh and the Founding Advisory Board for the Delfina Foundation, London/Damascus.